In Situ Molecular Pathology and Co-Expression Analyses

Gerard J. Nuovo - 2020

Overview

Significant progress in in situ molecular pathology has occurred since the first edition. This second edition continues to provide both the molecular basis for these improvements and practical protocols, distinguishing it from simpler "cook-book" approaches. The fields of in situ hybridization and immunohistochemistry have rapidly advanced, with computer-based analysis systems greatly enhancing their power. Understanding the improvements in reagents and the basics of in situ tests, protocols, and biochemistry is crucial for troubleshooting and maximizing the use of automated platforms.

Who it's for

• Molecular pathologists
• Diagnostic pathologists
• Laboratory directors
• Toxicologists
• Researchers and clinicians in training

Key features

• Focuses on simultaneous detection of multiple targets within intact tissue.
• Provides straightforward protocols for co-expression analyses.
• Details advancements in reagents and automated platforms.
• Covers the molecular basis and practical application of techniques.
• Includes data derived from in situ hybridization and immunohistochemistry.